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Efficacy of pre-surgical axitinib for shrinkage of inferior vena cava thrombus in a patient with advanced renal cell carcinoma.

Authors
  • Sassa, Naoto
  • Kato, Masashi
  • Funahashi, Yasuhito
  • Maeda, Motohiro
  • Inoue, Satoshi
  • Gotoh, Momokazu
Type
Published Article
Journal
Japanese Journal of Clinical Oncology
Publisher
Oxford University Press
Publication Date
Apr 01, 2014
Volume
44
Issue
4
Pages
370–373
Identifiers
DOI: 10.1093/jjco/hyu014
PMID: 24571808
Source
Medline
Keywords
License
Unknown

Abstract

The authors present the first case report of pre-surgical axitinib treatment on primary renal tumor and vena cava thrombus. We report the case of a 78-year-old woman with renal cell carcinoma and inferior vena cava tumor thrombus, successfully downstaged with pre-surgical therapy with axitinib. A significant objective response was observed for tumor size and thrombus. After initiation of axitinib therapy, computed tomography showed a decrease, from 57 to 51 mm, in the maximal renal tumor diameter. The tumor thrombus had shortened to 42 mm and had moved to the inferior hepatic vein (Levels 4-3), thereby obviating the need for thoracotomy. The patient finally accepted surgical treatment. Our case was enabled to perform less surgery for advanced renal cell carcinoma with tumor thrombus using axitinib as a pre-surgical therapy.

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