Affordable Access

[Efficacy of methylprednisolone pulse and mild hypothermia therapies in patients with acute encephalopathy].

Authors
  • Kimura, S1
  • Ohtsuki, N
  • Adachi, K
  • Nezu, A
  • Aihara, Y
  • 1 Department of Pediatrics, Urafune Hospital of Yokohama City University, School of Medicine.
Type
Published Article
Journal
No to hattatsu = Brain and development
Publication Date
Jan 01, 2000
Volume
32
Issue
1
Pages
62–67
Identifiers
PMID: 10655754
Source
Medline
License
Unknown

Abstract

Five patients with acute encephalopathy underwent methylprednisolone pulse (mPSL-P), hypothermia and their combination therapies (3 cases, 1 case and 1 case, respectively), with excellent outcome. Two cases with severe brain edema survived. One had severe brain damage as a sequelae. The remaining one recovered well after the combination therapy with mPSL-p and mild hypothermia, despite complete obstruction of the fourth ventricle on the first CT scan; the sequelae, hemiplegia and intelligent disturbance, was only mild. Four patients who received mPSL-P therapy within 6 hours after the onset of CNS symptoms recovered well though one was left with epilepsy. These results indicate that mPSL-P and/or hypothermia therapy will be chosen as the treatment of acute encephalopathy.

Report this publication

Statistics

Seen <100 times