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Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial.

Authors
  • Li, Qiang-Qiang1, 2
  • Xie, Ya-Dong1, 2
  • Liang, Wen-Qiang1, 2
  • Yang, Guo-Qing1, 2
  • Zhang, Huai-Bin1, 2
  • Wang, Yong-Ping2
  • 1 The First Clinical Medical College of Lanzhou University.
  • 2 Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou City, Gansu Province, China. , (China)
Type
Published Article
Journal
Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 11, 2020
Volume
99
Issue
50
Identifiers
DOI: 10.1097/MD.0000000000023517
PMID: 33327296
Source
Medline
Language
English
License
Unknown

Abstract

Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. This study will be submitted to a peer-reviewed journal for publication. We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY2020110005.

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