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Efficacy of glucarpidase (carboxypeptidase g2) in patients with acute kidney injury after high-dose methotrexate therapy.

Authors
  • Widemann, Brigitte C
  • Schwartz, Stefan
  • Jayaprakash, Nalini
  • Christensen, Robbin
  • Pui, Ching-Hon
  • Chauhan, Nikhil
  • Daugherty, Claire
  • King, Thomas R
  • Rush, Janet E
  • Howard, Scott C
Type
Published Article
Journal
Pharmacotherapy
Publication Date
May 01, 2014
Volume
34
Issue
5
Pages
427–439
Identifiers
DOI: 10.1002/phar.1360
PMID: 24132809
Source
Medline
Keywords
License
Unknown

Abstract

Glucarpidase caused a clinically important 99% or greater sustained reduction of serum methotrexate levels and provided noninvasive rescue from methotrexate toxicity in renally impaired patients.

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