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Efficacy of Endobiliary Radiofrequency Ablation using a Novel Endoluminal Radiofrequency Ablation Catheter in a Swine Model.

Authors
  • Choi, Hyun-Ho1
  • Shin, Ok-Ran2
  • Kim, Hyung-Keun1
  • Jeon, Bu-Seok1
  • Park, Yong-Won1
  • Kim, Sang-Woo1
  • Kim, Sung-Soo1
  • Chae, Hiun-Suk1
  • Lee, Soo Vin3
  • 1 Division of Gastroenterology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea. , (North Korea)
  • 2 Department of Hospital Pathology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea. , (North Korea)
  • 3 Laboratory Animal Research Center, Korea University College of Medicine, Seoul, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Publication Date
Dec 01, 2019
Volume
32
Issue
8
Pages
731–737
Identifiers
DOI: 10.1080/08941939.2018.1489566
PMID: 30380344
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Purpose: Endobiliary radiofrequency ablation (RFA) is a new endoscopic ablative technique. However, the ideal power setting for RFA has not yet been clarified. Therefore, we intended to evaluate the effects of endobiliary RFA according to time variations using novel RFA. Materials and methods: Nine female pigs were divided into three groups according to ablation time (60, 90, and 120 seconds) with the same setting (10 watts, 80 °C). All pigs underwent endoscopic retrograde cholangiography (ERC) and endobiliary RFA in the common bile duct. Gross and histologic examinations were performed after 24 hours. Results: The ERC and application of the endobiliary RFA were 100% successful, and the post-RFA cholangiogram did not show contrast leakage. The median depth of microscopic ablation was significantly different among the three groups (60 vs. 90 vs. 120 seconds = 1.90 (1.17-2.23) vs. 2.44 (2.31-2.60) vs. 2.52 (2.47-2.64) mm, p = 0.018). There was also a linear relationship between ablation time and microscopic ablation depth (r2 = 0.552, p = 0.002). However, no significant differences in macroscopic or microscopic ablation length were observed. In addition, there were focal ablation injuries in adjacent liver tissue in five of the nine pigs (2/3 in 60, 1/3 in 90, and 2/3 in 120 seconds). Conclusion: Endobiliary RFA using a novel RFA catheter resulted in controlled ablation with a linear relationship between microscopic ablation depth and ablation time in a swine model. Clinical studies are needed to validate the safe energy condition of endobiliary RFA in malignant biliary obstruction.

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