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Efficacy of Dipeptide-Coated Magnetic Nanoparticles in Lung Cancer Models Under Pulsed Electromagnetic Field.

Authors
  • Baskar, Ganga1
  • Ravi, Mathangi1
  • Panda, Jiban Jyoti2, 3
  • Khatri, Anjali2
  • Dev, Bhawna4
  • Santosham, Roy4
  • Sathiya, Sekar5
  • Babu, Chidambaram Saravana5
  • Chauhan, Virander Singh2
  • Rayala, Suresh K6
  • Venkatraman, Ganesh1, 7
  • 1 a Department of Human Genetics , Sri Ramachandra University , Chennai , India. , (India)
  • 2 b International Centre for Genetic Engineering and Biotechnology , New Delhi , India. , (India)
  • 3 c Institute of Nano Science and Technology , Mohali , Punjab , India. , (India)
  • 4 d Department of Radiology , Sri Ramachandra University , Chennai , India. , (India)
  • 5 e Centre for Toxicology and Developmental Research , Sri Ramachandra University , Chennai , India. , (India)
  • 6 f Department of Biotechnology , Indian Institute of Technology , Madras, Chennai , India. , (India)
  • 7 g Centre for Biomedical Nanotechnology , Sri Ramachandra University , Chennai , India. , (India)
Type
Published Article
Journal
Cancer Investigation
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jul 03, 2017
Volume
35
Issue
6
Pages
431–442
Identifiers
DOI: 10.1080/07357907.2017.1318894
PMID: 28537455
Source
Medline
Keywords
License
Unknown

Abstract

Lung cancer is the leading cause of cancer deaths and the overall 5-year survival rate is less than 17%. Hyperthermia is an alternative approach for the treatment of lung cancer and is associated with fewer side effects. We employed ironoxide nanoparticles in inducing localized hyperthermia in lung cancer cells using a pulsed electromagnetic field (PEMF). We synthesized, characterized and determined the uptake of dipeptide-coated iron oxide nanoparticles. Further, their ability in inducing localized hyperthermia in PEMF on lung cancer cells was assessed. Results showed nanoparticles are non-cytotoxic and showed enhanced cellular uptake in lung cancer cells. In vivo studies in nude mice lung tumor xenografts confirmed the presence in the tumors. Lung cancer cells pretreated with dipeptide-coated magnetic nanoparticles upon PEMF exposure induced cell death.

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