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Efficacy of clonidine in treatment of alcohol withdrawal state.

Authors
Type
Published Article
Journal
Psychopharmacology
Publication Date
Volume
81
Issue
1
Pages
78–80
Identifiers
PMID: 6415735
Source
Medline
License
Unknown

Abstract

Clonidine hydrochloride 5 micrograms/kg and placebo were given orally to 11 patients experiencing well-developed alcohol withdrawal states. Active drug and placebo were given in a randomised, cross-over double blind fashion 2 h apart. Clonidine significantly suppressed heart rate (P = 0.002), arterial blood pressure (P = 0.006), and an accumulated score of withdrawal symptoms and signs (P = 0.004). These data suggest that clonidine may be useful in the management of alcohol withdrawal states, and that the underlying pathophysiology of at least some of these manifestations may be sympathetic nervous system hyperactivity.

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