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Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature.

Authors
Type
Published Article
Journal
JAMA
Publication Date
Volume
271
Issue
9
Pages
698–702
Identifiers
PMID: 8309034
Source
Medline
License
Unknown

Abstract

On average, BCG vaccine significantly reduces the risk of TB by 50%. Protection is observed across many populations, study designs, and forms of TB. Age at vaccination did not enhance predictiveness of BCG efficacy. Protection against tuberculous death, meningitis, and disseminated disease is higher than for total TB cases, although this result may reflect reduced error in disease classification rather than greater BCG efficacy.

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