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The effects of zileuton and montelukast in reperfusion-induced arrhythmias in anesthetized rats.

Authors
  • Gonca, Ersöz1
  • 1 Biology Department, Faculty of Arts and Sciences, Bülent Ecevit University, İncivez/Zonguldak, Turkey. , (Turkey)
Type
Published Article
Journal
Current Therapeutic Research
Publisher
Elsevier
Publication Date
Dec 01, 2013
Volume
75
Pages
27–32
Identifiers
DOI: 10.1016/j.curtheres.2013.06.001
PMID: 24465039
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

5-Lipoxygenase is an enzyme involved in the synthesis of leukotriene eicosanoids from arachidonic acid. The therapeutic potential of zileuton, an inhibitor of 5-lipoxygenase, and montelukast, a cysteinyl leukotriene receptor antagonist, for the treatment of ischemia/reperfusion (I/R) injury of the heart has been proposed in a few studies. However, the effects of zileuton and montelukast on I/R-induced arrhythmias have not been determined. We assessed the possible protective effects of zileuton and montelukast against I/R-induced arrhythmias. Forty-five male Wistar albino rats were divided into 5 groups, each containing 9 rats. Group 1: control, Groups 2 and 3: rats treated with montelukast (10 and 30 mg/kg IP); and Groups 4 and 5: rats treated with zileuton (1 and 3 mg/kg IV) 15 minutes before the induction of ischemia. Ischemia and reperfusion were induced by occluding the left main coronary artery of anesthetized rats for 6 minutes followed by reopening the artery for 6 minutes. Both doses of zileuton decreased the mean [SE] arrhythmia score (zileuton 1 mg/kg: 1.4 [0.8]; zileuton 3 mg/kg: 1.3 [0.5] vs control: 2.9 [0.3]; P < 0.05), the duration of ventricular tachycardia, and the total length of arrhythmias, but montelukast was not effective to decrease the ventricular arrhythmias during the 6 minutes of reperfusion. The results indicate for the first time that zileuton exerts an antiarrhythmic effect at different doses and that montelukast is not effective against I/R-induced arrhythmias. These results indicate that zileuton may be a candidate for drug treatment of I/R-induced arrhythmias.

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