Affordable Access

Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells.

Authors
  • Zhao, Qiu
  • Du, Jing
  • Gu, Hua
  • Teng, Xiaoli
  • Zhang, Qing
  • Qin, Hua
  • Liu, Nanzhi
Type
Published Article
Journal
Pancreas
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2007
Volume
34
Issue
2
Pages
242–247
Identifiers
PMID: 17312464
Source
Medline
License
Unknown

Abstract

YC-1 inhibits HIF-1alpha expression in hypoxic pancreatic cancer cells, which is accompanied by the translocation of HIF-1alpha from nucleus to cytoplasm, decreased mRNA expression of VEGF and GPI, reduced cell proliferative vitality, and increased apoptosis. These results suggest that HIF-1 is a potential therapeutic target for pancreatic cancer.

Report this publication

Statistics

Seen <100 times