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Effects of xylitol and fluoride on the response to glucose pulses of Streptococcus mutans T8 growing in continuous culture.

Authors
  • Rogers, A H
  • Bert, A G
Type
Published Article
Journal
Oral microbiology and immunology
Publication Date
Apr 01, 1992
Volume
7
Issue
2
Pages
124–126
Identifiers
PMID: 1528632
Source
Medline
License
Unknown

Abstract

Streptococcus mutans T8 was grown glucose-limited at pH 7.0 in a chemostat and pulsed, under pH free-fall conditions, with glucose, xylitol or a mixture of the two. Experiments were conducted in the absence or continual presence of low levels (1 mmol.l-1) of fluoride. Culture filtrates of samples taken at frequent intervals were assayed for carbohydrate and fermentation end-products. Fluoride had little effect on the organism's response to glucose until the culture pH fell to ca. 5.0, at which point the rate of lactate production was reduced some 3-fold. Xylitol affected the response to glucose but its effect was most marked in the presence of fluoride. Under these conditions, the rate of lactate production was reduced at least 3-fold, the pH did not fall to 5.0 and only about 50% of the added glucose was consumed. This suggests that xylitol can augment the metabolic effects on S. mutans of low levels of fluoride.

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