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Effects of In vitro hemodilution, hypothermia and rFVIIa addition on coagulation in human blood.

Authors
  • Darlington, Daniel N
  • Kremenevskiy, Igor
  • Pusateri, Anthony E
  • Scherer, Michael R
  • Fedyk, Chriselda G
  • Kheirabaldi, Bijan S
  • Delgado, Angel V
  • Dubick, Michael A
Type
Published Article
Journal
International journal of burns and trauma
Publication Date
Jan 01, 2012
Volume
2
Issue
1
Pages
42–50
Identifiers
PMID: 22928166
Source
Medline
Keywords
License
Unknown

Abstract

Theses data show that thrombin generation is affected by hypothermia, but not 40% dilution. TEG is affected by 40% dilution with Hextend, but not by hypothermia. PT and aPTT are significantly affected by both hypothermia and dilution. Recombinant FVIIa caused a greater change in thrombin generation at 34°C as compared to 37°C, and a greater change in PT at 40% dilution, suggesting that the effect of rFVIIa on coagulation is both temperature and dilution dependant.

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