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Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients

Authors
  • Kloc, Malgorzata1, 2, 3
  • Ghobrial, Rafik M.1, 2
  • Lipińska-Opałka, Agnieszka4
  • Wawrzyniak, Agata4
  • Zdanowski, Robert5
  • Kalicki, Boleslaw4
  • Kubiak, Jacek Z.6, 7
  • 1 The Houston Methodist Research Institute, Houston, TX 77030, USA
  • 2 The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA
  • 3 The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston, TX, USA
  • 4 Military Institute of Medicine, Clinic of Paediatrics, Nephrology and Child Allergology, Central Clinical Hospital of the Ministry of National Defense, Warsaw, Poland
  • 5 Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine (WIM), Warsaw, Poland
  • 6 Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland
  • 7 UnivRennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Cell Cycle Group, Faculty of Medicine, Rennes, France
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Dec 16, 2020
Volume
360
Pages
104259–104259
Identifiers
DOI: 10.1016/j.cellimm.2020.104259
PMID: 33359760
PMCID: PMC7738277
Source
PubMed Central
Keywords
Disciplines
  • Review Article
License
Unknown

Abstract

Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.

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