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Effects of unipolar stimulation on voltage and calcium distributions in the isolated rabbit heart.

Authors
  • Sidorov, Veniamin Y1
  • Holcomb, Mark R
  • Woods, Marcella C
  • Gray, Richard A
  • Wikswo, John P
  • 1 Dept. of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Type
Published Article
Journal
Basic research in cardiology
Publication Date
Nov 01, 2008
Volume
103
Issue
6
Pages
537–551
Identifiers
DOI: 10.1007/s00395-008-0740-1
PMID: 18642125
Source
Medline
License
Unknown

Abstract

Changes in the [Ca(2+)](i) distribution correlate with the behavior of the V (m) distribution for S1-S2 coupling intervals longer than 20 ms; at shorter intervals S2 creates more heterogeneous [Ca(2+)](i) distribution in comparison with V(m). Stimulation in diastole and at very short coupling intervals caused V(m)-[Ca(2+)](i) uncoupling at the regions of positive polarization (virtual cathode).

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