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[Effects of therapies on childhood systemic lupus erythematosus].

Authors
  • Kurosawa, Rumiko
  • Umezawa, Remi
  • Kobayashi, Yoshinori
  • Nakajima, Shoko
  • Miyamae, Takako
  • Ito, Shuichi
  • Imagawa, Tomoyuki
  • Katakura, Shigeki
  • Mori, Masaaki
  • Aihara, Yukoh
  • Yokota, Shumpei
Type
Published Article
Journal
Ryūmachi. [Rheumatism]
Publication Date
Oct 01, 2003
Volume
43
Issue
4
Pages
632–637
Identifiers
PMID: 14598654
Source
Medline
License
Unknown

Abstract

We analyzed the effects of three therapies on 30 patients with childhood systemic lupus erythematosus, and classified the patients into three groups. The therapies were as follows; Group A (8 cases), methylpredni-solone (mPSL) pulses plus oral prednisolone (PSL) alone, Group B (10 cases), mPSL pulses plus oral PSL and mizoribine (MZB) or azathioprine (AZP), Group C (12 cases), mPSL pulses and intravenous cyclophosphamide (IVCY) pulse therapy plus oral PSL and MZB or AZP. Three years after treatment, we compared the laboratory data (C3, C4, CH50 and anti-DNA antibody), the SLEDAI scores and numbers of relapses in these three groups. We demonstrated that group C had the best data, and this data indicated that the median C3, C4 and CH50 increased and that the median anti-DNA antibody and the mean of the numbers of relapses decreased. In conclusion, the combination of immunosuppressants and IVCY appeared to offer great benefits in childhood systemic lupus erythematosus.

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