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Effects of α-thalassaemia mutations on the haematological parameters of β-thalassaemia carriers.

Authors
  • Saleh-Gohari, Nasrollah1
  • Khademi Bami, Maryam2
  • Nikbakht, Roya3
  • Karimi-Maleh, Hassan4
  • 1 Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. , (Iran)
  • 2 Genetic Laboratory, Afzalipour Hospital, Kerman, Iran. , (Iran)
  • 3 Department of Biostatistics and Epidemiology, Research Centre for Modelling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. , (Iran)
  • 4 Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. , (Iran)
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
Jul 01, 2015
Volume
68
Issue
7
Pages
562–566
Identifiers
DOI: 10.1136/jclinpath-2014-202825
PMID: 25935548
Source
Medline
Keywords
License
Unknown

Abstract

We conclude that co-inheritance of α- and β-thalassaemia mutations may result in misdiagnosis of β-thalassaemia carriers. Therefore, in genetic counselling of patients with a near-normal range of blood cell indices the possibility that they may carry α, β-thalassaemia mutations must be considered.

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