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Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study.

Authors
  • Zhao, Y
  • Wen, G
  • Qiao, Z
  • Xu, H
  • Sun, Q
  • Huang, H
  • Shan, S
  • Mu, Z
  • Zhang, J
Type
Published Article
Journal
Lupus
Publisher
SAGE Publications
Publication Date
Apr 01, 2013
Volume
22
Issue
5
Pages
469–476
Identifiers
DOI: 10.1177/0961203313478302
PMID: 23554035
Source
Medline
License
Unknown

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Arsenic trioxide (ATO) has been used in lupus-prone mice with a regulatory effect on immune abnormality. Tetra-arsenic tetra-sulfide (As4S4), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects than ATO. In this study, a pilot study was performed to investigate the effects and the mechanism of As4S4 on the lupus-prone BXSB mice. Improvement of monocytosis (p<0.05) in spleen and decreased serum interleukin-6 (IL-6) (p=0.0277) were observed with As4S4 treatment. As4S4-treated mice exhibited amelioration of skin, liver and renal disease with mild side effects. Histological analysis revealed that As4S4 suppressed immune complex deposition, mesangial proliferation and inflammatory cell infiltration in kidney and liver. Our study support that As4S4 selectively suppresses cutaneous lupus and nephritis in BXSB mice and might be a potential treatment for SLE.

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