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Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells.

Authors
  • Pelaia, G1
  • Gallelli, L
  • Renda, T
  • Fratto, D
  • Falcone, D
  • Caraglia, M
  • Busceti, M T
  • Terracciano, R
  • Vatrella, A
  • Maselli, R
  • Savino, R
  • 1 Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Cell Proliferation
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2012
Volume
45
Issue
6
Pages
557–565
Identifiers
DOI: 10.1111/j.1365-2184.2012.00846.x
PMID: 23045963
Source
Medline
License
Unknown

Abstract

In both GLC-82 and CALU-1 cell lines, simvastatin and R115777 significantly reduced ERK phosphorylation; this effect, which reached the greatest intensity after 36 h treatment, was paralleled by a concomitant induction of apoptosis, documented by significant increase in both caspase-3 activation and TUNEL-positive cells, associated with a reduction in cell numbers. Our results thus suggest that simvastatin and R115777 may exert, in susceptible lung cancer cell phenotypes, a pro-apoptotic and anti-proliferative activity, which appears to be mediated by inhibition of the Ras/Raf/MEK/ERK signalling cascade.

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