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The effects of sodium pump inhibitors on sensory ganglion neurite growth.

Authors
  • Penniyainen, V A
  • Lopatina, E V
  • Tsyrlin, V A
  • Krylov, B V
Type
Published Article
Journal
Neuroscience and behavioral physiology
Publication Date
Mar 01, 2009
Volume
39
Issue
3
Pages
301–304
Identifiers
DOI: 10.1007/s11055-009-9130-x
PMID: 19234795
Source
Medline
License
Unknown

Abstract

The effects of sodium pump inhibitors of the cardiac glycoside family (strophanthin K and digoxin) on neurite growth in the sensory ganglia of chick embryos (10-12 days) were studied in organotypic tissue cultures. These experiments produced the first evidence that these medicinal agents have marked neurite-suppressing actions. Their effects on sensory ganglion neurite growth were dose-dependent. At 1.10(-6) M, strophanthin K and digoxin completely blocked sensory ganglion neurite growth. Addition of study compounds to the medium at a concentration of 1.10(-7) M decreased the area index of the experimental explants to a level significantly below that of the controls, by a mean of 45%. These strophanthin K and digoxin concentrations were comparable with those at which endogenous digitalis-like factors are present in the systemic circulation. These results provide evidence that cardiac glycosides can produce the directed regulation of nervous tissue growth by affecting the signal transducer Na+, K+-ATPase.

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