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Effects of sleep on wake-induced c-fos expression.

Authors
  • Basheer, R1
  • Sherin, J E
  • Saper, C B
  • Morgan, J I
  • McCarley, R W
  • Shiromani, P J
  • 1 VA Medical Center and Harvard Medical School, Brockton, Massachusetts 02401, USA.
Type
Published Article
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Publication Date
Dec 15, 1997
Volume
17
Issue
24
Pages
9746–9750
Identifiers
PMID: 9391027
Source
Medline
License
Unknown

Abstract

We investigated the effects of sleep on wake-induced c-fos expression in the cerebral cortex of rats and c-fos-lacZ transgenic mice. In the cortex of rats, the levels of c-Fos, detected both by immunocytochemistry and Western blot, remained high during 6 or 12 hr of enforced wakefulness but declined rapidly (within 1 hr) with increasing time of recovery sleep. Similarly, in the transgenic mice in which lacZ expression is driven from the c-fos promoter, beta-galactosidase activity was high after enforced wakefulness and declined with increasing amounts of sleep. These results suggest that the decrease in c-Fos protein in cortical neurons during sleep may be attributable to cessation of c-fos expression, activation of a process that degrades the wake-induced c-Fos, or both.

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