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Effects of shear stress on differentiation of stem cells into endothelial cells.

Authors
  • Huang, Yan1
  • Qian, Jia-Yi1
  • Cheng, Hong1
  • Li, Xiao-Ming2
  • 1 Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China. , (China)
  • 2 Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China. [email protected] , (China)
Type
Published Article
Journal
World journal of stem cells
Publication Date
Jul 26, 2021
Volume
13
Issue
7
Pages
894–913
Identifiers
DOI: 10.4252/wjsc.v13.i7.894
PMID: 34367483
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Stem cell transplantation is an appealing potential therapy for vascular diseases and an indispensable key step in vascular tissue engineering. Substantial effort has been made to differentiate stem cells toward vascular cell phenotypes, including endothelial cells (ECs) and smooth muscle cells. The microenvironment of vascular cells not only contains biochemical factors that influence differentiation but also exerts hemodynamic forces, such as shear stress and cyclic strain. More recently, studies have shown that shear stress can influence the differentiation of stem cells toward ECs. A deep understanding of the responses and underlying mechanisms involved in this process is essential for clinical translation. This review highlights current data supporting the role of shear stress in stem cell differentiation into ECs. Potential mechanisms and signaling cascades for transducing shear stress into a biological signal are proposed. Further study of stem cell responses to shear stress will be necessary to apply stem cells for pharmacological applications and cardiovascular implants in the realm of regenerative medicine. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

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