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Effects of serine protease and deoxyribonuclease on intravascular tumor cell arrest in rat blood-borne lung metastasis.

Authors
  • Tokita, K
  • Sugihara, S
  • Hiraoka, T
  • Miyauchi, Y
  • Kambara, T
  • Yamamoto, T
Type
Published Article
Journal
Invasion & metastasis
Publication Date
Jan 01, 1995
Volume
15
Issue
1-2
Pages
46–59
Identifiers
PMID: 7672931
Source
Medline
License
Unknown

Abstract

Effects of alpha-chymotrypsin and deoxyribonuclease I (DNase I) on the early phase of blood-borne lung metastasis in rats were studied using confocal laser scanning microscopy and AH-109A cells labeled either with carboxyfluorescein diacetate succinimyl ester or with 51Cr. Intravenous administration of alpha-chymotrypsin or DNase I appeared to enhance or inhibit, respectively, the tumor cell arrest in lung microvasculature as a reflection of reduction or promotion of the tumor cell clearance in the microvasculature. These results suggest that the effects of alpha-chymotrypsin and DNase I are related to induction of tumor cell aggregation and disaggregation in the blood stream, respectively.

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