Affordable Access

Access to the full text

The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection

Authors
  • Rees, H.1
  • Sluka, Kathleen A.1
  • Urban, Laszlo2
  • Walpole, Chris J.2
  • Willis, W. D.1
  • 1 Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555–1069, USA e-mail: [email protected], Fax: +1–409-772-4687, US
  • 2 Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK, GB
Type
Published Article
Journal
Experimental Brain Research
Publisher
Springer-Verlag
Publication Date
Aug 01, 1998
Volume
121
Issue
3
Pages
355–358
Identifiers
DOI: 10.1007/s002210050468
Source
Springer Nature
Keywords
License
Yellow

Abstract

Substance P, acting through neurokinin I receptors, is involved in the processing of nociceptive information in the spinal cord. Sensitization of spinothalamic tract neurons occurs to low-intensity stimuli following capsaicin injection. The current study tested the effects of the novel neurokinin 1 receptor antagonist, SDZ NKT 343, on the sensitization of spinothalamic tract cells by capsaicin in monkeys. Spinothalamic tract cells from the lumbar enlargement with receptive fields in the hindpaw were isolated and recorded before and after intradermal injection of capsaicin. The background activity and responses to brushing, pressing and pinching the skin were assessed. Thirty minutes after capsaicin injection there was an increase in background activity and responses to brush and pressure applied to the receptive field. Infusion of SDZ NKT 343 (for 30–45 min) significantly reversed the increased response to brushing without affecting the increased background activity or the increased response to pressure. Thus, blockade of neurokinin 1 receptors reduces the sensitized responses to innocuous mechanical stimuli but not to noxious mechanical stimuli.

Report this publication

Statistics

Seen <100 times