Affordable Access

The effects of sar1ala8-angiotensin II in vasopressin-treated dehydrated sheep.

Authors
  • Kelly, C
  • Wholohan, T
  • Yesberg, N E
Type
Published Article
Journal
Quarterly journal of experimental physiology (Cambridge, England)
Publication Date
Apr 01, 1983
Volume
68
Issue
2
Pages
161–166
Identifiers
PMID: 6856746
Source
Medline
License
Unknown

Abstract

Mildly dehydrated conscious Merino ewes were infused with vasopressin (AVP) at 5 mu x min-1 alone and simultaneously with the angiotensin II receptor blocker sar1ala8-angiotensin II (saralasin) at 15 micrograms x min-1. AVP was slightly pressor and produced an increase in the calculated total peripheral resistance, and an increase in glomerular filtration rate, urine flow and electrolyte excretion, without a change in total renal plasma flow. These results indicate renal efferent arteriolar vasoconstriction as well as other non-renal vasoconstriction. Saralasin infusion checked the rise in total peripheral resistance (which continued to increase after saralasin withdrawal), but caused a marked increase in renal vascular resistance resulting in a decrease in renal plasma flow and to a lesser extent in glomerular filtration rate. These results suggest that saralasin was acting as an angiotensin II agonist in the kidney, but as an antagonist elsewhere. Deductions from previous experiments in the literature of the renal function of angiotensin II, based on its supposed inhibition by saralasin, may not be justified.

Report this publication

Statistics

Seen <100 times