Roof shape and slope are both important parameters for the safety of a structure, especially when facing wind loads. The present study demonstrates the pressure variations due to wind load on the pyramidal roof of a square plan low-rise building with 15% wall openings through CFD (Computational Fluid Dynamics) simulation. Many studies on roofed structures have been performed in the past; however, a detailed review of the literature indicates that the majority of these studies focused on flat, hip, gable and spherical roofs only. There is a lack of research that analyses these effects on pyramidal roof buildings. ANSYS (Analysis System) ICEM (Integrated Computer Engineering and Manufacturing)-CFD and ANSYS Fluent commercial packages have been used for modelling and simulation, respectively, and ANSYS CFD Post was used to obtain the results. A realizable k–ε turbulent model was used for the pressure distribution on the roof of the building model. In the present study, twenty-four models with different roof slopes (α), i.e. 0°, 10°, 20°, and 30°, with various wind incidence angles (ϴ), i.e. 0°, 15°, 30°, 45°, 60° and 75° were investigated. The influence of roof slope and wind incidence angle are analysed in this study. Results have been represented through pressure coefficient (Cp) contours on the roof surface and velocity streamlines of the flow field of the different cases. The optimization of the roof slope may be achieved by considering different wind incidence angles for buildings so that they may better withstand wind force in a specific area. When wind pressure coefficients from building models with openings were compared with pressure coefficients from building models without openings, it was found that the pressure coefficients for building models without openings are almost twice or three times that of the pressure coefficients for models with openings.