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Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.

Authors
  • Liu, Ying
  • Kagechika, Hiroyuki
  • Ishikawa, Junko
  • Hirano, Hitoshi
  • Matsukuma, Satoshi
  • Tanaka, Kazuko
  • Nakamura, Shoji
Type
Published Article
Journal
Journal of Neurochemistry
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2008
Volume
106
Issue
3
Pages
1104–1116
Identifiers
DOI: 10.1111/j.1471-4159.2008.05445.x
PMID: 18466335
Source
Medline
License
Unknown

Abstract

Vitamin A-derived retinoic acids (RAs) are known to exert a variety of biological actions, including modulatory effects on cell differentiation and apoptosis. A recent study has demonstrated that 13-cis-RA and all-trans-RA suppressed neurogenesis in the dentate gyrus of the hippocampus in adult mice. The present experiments were performed to see whether 13-cis-RA and all-trans-RA could alter the dendritic morphology of cultured hippocampal neurons via RA receptors: retinoic acid receptor (RAR) and retinoid X receptor (RXR). High doses of 13-cis-RA and all-trans-RA exerted a negative effect on the cultured hippocampal neurons, while a low dose of 13-cis-RA but not all-trans-RA caused a positive effect. The negative changes induced by 13-cis-RA and all-trans-RA were antagonized by RXR antagonists and RAR antagonists, respectively. The positive changes induced by a low dose of 13-cis-RA were blocked by both RXR antagonists and RAR antagonists. These results suggest that RAs at high concentrations cause a negative effect on the dendritic morphology of cultured hippocampal neurons through RA receptors, while RAs at low concentrations exert a positive influence on cultured hippocampal neurons.

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