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Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain.

Authors
  • Gobbi, M
  • Bergami, A
  • Caltavuturo, C
  • Valle, F D
  • Mennini, T
  • Caccia, S
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Nov 15, 1996
Volume
219
Issue
1
Pages
5–8
Identifiers
PMID: 8961290
Source
Medline
License
Unknown

Abstract

The effects of oral dexnorfenfluramine (DNF; 1-4 mg/kg, twice daily for 4 days), the active metabolite of dexfenfluramine, were examined on rat regional brain indole contents and [3H]citalopram binding. Two hours after the last dose, serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were dose-dependently lowered at doses above 1.5 mg/kg, with slight regional differences. Cortical 5-HT uptake sites were reduced only at the highest dose. Above 2 mg/kg DNF also caused a more lasting reduction (4 weeks) of regional indoles and cortical 5-HT uptake sites. At this longer time while the decrease in hippocampal 5-HT levels and cortical 5-HT uptake sites remained essentially constant, cortical and striatal 5-HT levels were lowered less than at 2 h, suggesting a return toward control values.

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