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The effects of radiofrequency hyperthermia on pain and function in patients with knee osteoarthritis: a preliminary report

  • Takahashi, Kenji1
  • Kurosaki, Hiromasa2
  • Hashimoto, Sanshiro3
  • Takenouchi, Kenji1
  • Kamada, Toshikazu4
  • Nakamura, Hiroshi1
  • 1 Nippon Medical School, Department of Rheumatology, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan , Tokyo (Japan)
  • 2 Cancro Clinic, 2-29-2 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan , Tokyo (Japan)
  • 3 Hashimoto Clinic, 2-16-7 Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan , Tokyo (Japan)
  • 4 Hara Orthopaedic Hospital, 3-36-23 Nishiikebukuro, Toshima-ku, Tokyo, 171-0021, Japan , Tokyo (Japan)
Published Article
Journal of Orthopaedic Science
Publication Date
May 25, 2011
DOI: 10.1007/s00776-011-0093-8
Springer Nature


BackgroundThe clinical evidence of the efficacy of hyperthermia on osteoarthritis (OA) has not yet been clearly established. In addition, the application of a modality that can control the temperature inside the joints has not been reported. The purpose of this study was to investigate the effect of percutaneous radiofrequency hyperthermia, which could safely raise the temperature of the body core, in patients with OA knees.MethodsTemperature changes inside the knee joint without OA were measured during exposure to radiofrequency. Radiofrequency hyperthermia was performed on 12 OA knees by exposure to 8 MHz and 200 W for 20 min, 3 times, at 1-week intervals. The clinical outcome was evaluated by use of the Lequesne index (LI) and the Japan Orthopaedic Association (JOA) scale. The osteoarthritis research society international (OARSI) responder criteria were also analyzed.ResultsRadiofrequency hyperthermia of 8 MHz and 200 W for 20 min increased the temperature inside the joint from 34.4 to 39.4°C. The LI decreased by 3.55 points from baseline during the 3 weeks. The JOA scale improved significantly during the period, reaching 86.25 points at the final examination from baseline of 67.5 points. 67% of patients had a response to the therapy according to OARSI criteria. No side effects were observed.ConclusionsRadiofrequency hyperthermia can safely increase the temperature inside the knee joint. Radiofrequency hyperthermia on OA knees provides a remarkable pain relief effect and can improve the patients’ daily life. In the future, clinical studies should be performed with a protocol containing more cases, with appropriate control groups.

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