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Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors.

Authors
  • Shibata, K
  • Hirasawa, A
  • Foglar, R
  • Ogawa, S
  • Tsujimoto, G
Type
Published Article
Journal
Circulation
Publication Date
Apr 07, 1998
Volume
97
Issue
13
Pages
1227–1230
Identifiers
PMID: 9570190
Source
Medline
License
Unknown

Abstract

The results show that all alpha1AR subtypes are expressed in the human cardiovascular system and that quinidine and verapamil may have a potent, synergistic inhibitory effect on the alpha1ARs. Clinically observed hypotension after quinidine plus verapamil can be explained by their synergistic inhibitory effects on human alpha1ARs.

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