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Effects of quercetin on microRNAs: A mechanistic review.

Authors
  • Akbari Kordkheyli, Vahid1
  • Khonakdar Tarsi, Abbas1
  • Mishan, Mohammad A2
  • Tafazoli, Alireza3, 4
  • Bardania, Hassan5
  • Zarpou, Setareh1
  • Bagheri, Abouzar1
  • 1 Department of Clinical Biochemistry-Biophysics and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. , (Iran)
  • 2 Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 3 Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland. , (Poland)
  • 4 Department of Endocrinology, Diabetology and Internal Medicine, Clinical Research Center, Medical University of Bialystok, 15-276 Bialystok, Poland. , (Poland)
  • 5 Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. , (Iran)
Type
Published Article
Journal
Journal of Cellular Biochemistry
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2019
Volume
120
Issue
8
Pages
12141–12155
Identifiers
DOI: 10.1002/jcb.28663
PMID: 30957271
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

MicroRNA (miRNA)-dependent pathways are one of the newest gene regulation mechanisms in various diseases, particularly in cancers. miRNAs are endogenous noncoding RNAs with about 18 to 25 nucleotide length, which can regulate the expression of at least 60% of human total genome posttranscriptionally. Quercetin is the most abundant flavonoid in a variety of fruits, flowers, and medical herbs, known as a strong free radical scavenger that could show antioxidant, anti-inflammatory, and antitumor activities. Recent studies also reported its strong impact on various miRNA expressions in different abnormalities. In this review, we aimed to summarize the studies focused on the effects of quercetin on different miRNA expressions to more clear the main possible mechanisms of quercetin influences and introduce it as a beneficial agent for regulation of miRNAs in various biological directions. © 2019 Wiley Periodicals, Inc.

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