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Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats.

Authors
  • Cortez, M Y1
  • Torgan, C E
  • Brozinick, J T Jr
  • Miller, R H
  • Ivy, J L
  • 1 Department of Kinesiology, University of Texas, Austin, TX 78712.
Type
Published Article
Journal
The American journal of clinical nutrition
Publication Date
Apr 01, 1991
Volume
53
Issue
4
Pages
847–853
Identifiers
PMID: 2008862
Source
Medline
License
Unknown

Abstract

Female obese Zucker rats (aged 6 wk) were randomly assigned to one of two control or one of three experimental-diet groups. Experimental diets contained 6% pyruvate (Pyr). 6% dihydroxyacetone (Dha), or 3% each pyruvate and dihydroxyacetone (Pyr-Dha). Control-group 1 was fed a normal diet ad libitum and control-group 2 was pair fed according to the experimental group with the lowest consumption. After 5 wk the rats receiving Pyr (357.5 +/- 12.7 g) were significantly lighter than pair-fed (385.9 +/- 4.9 g) and ad libitum-fed (404.3 +/- 10.1) controls. Resting oxygen consumption (mL.min-1.kg0.65) was significantly higher in Pyr-fed rats than in pair-fed controls and food-conversion efficiency was significantly decreased. Rats fed Pyr had a lower resting respiratory-exchange ratio than did ad libitum- and pair-fed controls (0.81 +/- 0.01 vs 0.88 +/- 0.01 and 0.87 +/- 0.01, respectively). Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation.

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