The Effects of Proximal and Distal Social Stimulation on Ethanol Intake in Male and Female CD-1 Mice

Affordable Access

Download Read

The Effects of Proximal and Distal Social Stimulation on Ethanol Intake in Male and Female CD-1 Mice

Authors
  • Arthur Tomie1
  • Allison Gayle Samuel2
  • Alam Merchant1
  • Lei Yu1
Type
Published Article
Journal
Journal of Drug and Alcohol Research
Publisher
Ashdin Publishing
Publication Date
Jan 03, 2016
Volume
5
Pages
1–9
Identifiers
DOI: 10.4303/jdar/235949
Source
Ashdin
Keywords
License
Green

Abstract

Background. Proximal and distal social stimulation increase ethanol drinking in humans. Purpose. Our study evaluated the effects of proximal and distal social stimulation on home-cage ethanol drinking in mice. Study design. Proximal cagemate drinking (PCD) procedures use a clear plastic barrier to separate the drinker mouse from the proximal cagemate mouse, to evaluate home-cage drinking of 10% ethanol and water. Eight groups of CD-1 mice were arranged in a 2 × 2 × 2 factorial design with two levels of sex of drinker (male vs. female), two levels of sex of cagemate (male vs. female), and two levels of distal group-housed mice in the colony room (present vs. absent). Results. Distal group-housed mice, located outside of the home cage, stimulated ethanol drinking in female drinkers and did so regardless of the sex of their proximal cagemate. This effect was observed in the male drinker but only when housed with a proximal male cagemate. Conclusion. This study provides the first report of distal social stimulation of ethanol drinking in mice. The distal social stimulation effect, like the effects of proximal social stimulation, was more pronounced in female drinkers.

Report this publication

Statistics

Seen 154 times
Downloaded <100 times