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[Effects of propofol on the activation of nuclear factor-kappaB and cardiomyocytes apoptosis during myocardial ischemia/reperfusion injury in rats].

Authors
  • Zhao, Song1
  • Xie, Li-Jun
  • Zhang, Jian-Xin
  • Li, Lan-Fang
  • 1 Hebei Medical University, Shijiazhuang 050017, China. , (China)
Type
Published Article
Journal
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Publication Date
Aug 01, 2010
Volume
26
Issue
3
Pages
291–295
Identifiers
PMID: 21038672
Source
Medline
License
Unknown

Abstract

Propofol could inhibit NF-kappaB activation and down-regulate the expression of caspase-3 and as a result suppress cardiomyocytes apoptotic initiation during the myocardium I/R injury, which may be one of the molecular mechanisms of its cardioprotection.

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