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Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.

Authors
  • Siervo, Mario
  • Riley, Heather L
  • Fernandez, Bernadette O
  • Leckstrom, Carl A
  • Martin, Daniel S
  • Mitchell, Kay
  • Levett, Denny Z H
  • Montgomery, Hugh E
  • Mythen, Monty G
  • Grocott, Michael P W
  • Feelisch, Martin
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
4
Identifiers
DOI: 10.1371/journal.pone.0094915
PMID: 24733551
Source
Medline
License
Unknown

Abstract

Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.

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