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Effects of programmed death ligand 1 on the prognosis of neuroblastoma

Authors
  • Wu, Zelin
  • Wei, Fenggui
  • Zou, Yawei
Type
Published Article
Journal
Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 05, 2021
Volume
100
Issue
9
Identifiers
DOI: 10.1097/MD.0000000000024920
PMID: 33655954
PMCID: PMC7939199
Source
PubMed Central
Keywords
License
Green

Abstract

Background: Previous studies have investigated the prognostic role of programmed death ligand 1 (PD-L1) expression in patients with neuroblastoma, while the results are still controversial. Therefore, we conducted a meta-analysis to clarify the relationship between the expression of PD-L1 and the prognosis of neuroblastoma. Methods: Search electronic databases include PubMed, Cochrane, Embase, Scopus and Web of Science, and the search time is set to build the database until January 2021. Hazard ratio (HR) and 95% confidence interval (CI) were used to analyze the included results. Meta-analysis was performed using Stata 15.0 software. Results: This review will be disseminated in print by peer-review. Conclusion: The study will provide updated evidence for the evaluation of whether the expression of PD-L1 is associated with poor prognosis in patients with neuroblastoma. Ethics and dissemination: The private information from individuals will not be published. This systematic review also should not damage participants’ rights. Ethical approval is not available. The results may be published in a peer-reviewed journal or disseminated in relevant conferences OSF Registration number: DOI 10.17605/OSF.IO/FBCY6.

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