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Effects of previous ovarian surgery on the follicular response to ovulation induction in an in vitro fertilization program.

Authors
  • Hornstein, M D
  • Barbieri, R L
  • McShane, P M
Type
Published Article
Journal
The Journal of reproductive medicine
Publication Date
Apr 01, 1989
Volume
34
Issue
4
Pages
277–281
Identifiers
PMID: 2497250
Source
Medline
License
Unknown

Abstract

This study examined the effects of previous ovarian surgery on the clinical response to ovulation induction with clomiphene citrate-human menopausal gonadotropin in an in vitro fertilization program. Patients were divided into five clinical groups: group A (n = 63), no previous ovarian surgery; B (n = 9), unilateral cystectomy; C (n = 6), unilateral oophorectomy with no contralateral ovarian surgery; D (n = 7), bilateral ovarian surgery with both ovaries present; and E (n = 4), unilateral oophorectomy and contralateral cystectomy. Patients in group E demonstrated significantly lower serum estradiol on cycle days 9-11 (P less than or equal to .05) and fewer follicles on cycle days 11-12 (P less than or equal to .05) than did patients in groups A-D. The percentage of cancelled cycles increased with increasing amounts of ovarian surgery (P less than or equal to .03). The study suggests that one cause of a poor response to ovulation induction for in vitro fertilization may be prior extensive ovarian surgery.

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