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Effects of Prenatal Stress on Serotoninergic Neurons in the Dorsal Raphe Nucleus and on Pain Behavior during the Neonatal Period of Development

Authors
  • Butkevich, I. P.
  • Barr, G. A.
  • Mikhailenko, V. A.
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Springer US
Publication Date
Oct 28, 2016
Volume
46
Issue
9
Pages
1005–1010
Identifiers
DOI: 10.1007/s11055-016-0345-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

The effects of prenatal stress on the immunocytochemical reaction for serotonin (5-HT) in the dorsal raphe nucleus (DRN) were studied in seven-day-old male rat pups subjected to pain in the formalin test (inflammatory pain; controls received injections of physiological saline. Prenatal stress enhanced the animals’ pain behavior in the formalin test. Prenatal stress decreased the numbers of 5-HT-immunoreactive cells as compared to those in prenatally unstressed animals, both in rat pups with inflammatory pain and in controls. The formalin treatment did not alter the number of 5-HT-immunoreactive cells in the DRN in rat pups in either prenatally stressed or unstressed animals. Thus, we demonstrate that 5-HT-ergic neurons in the brainstem DRN in seven-day-old rat pups are the targets of prenatal stress. We suggest that stress due to separation from the mother during the experiment masked differences in the immunocytochemical parameters in rat pups with inflammatory pain and in controls.

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