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Effects of platelet activating factor on mouse oocyte fertilization in vitro.

Authors
  • Minhas, B S
  • Kumar, R
  • Ricker, D D
  • Roudebush, W E
  • Dodson, M G
  • Fortunato, S J
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Publication Date
Dec 01, 1989
Volume
161
Issue
6 Pt 1
Pages
1714–1717
Identifiers
PMID: 2603931
Source
Medline
License
Unknown

Abstract

Platelet activating factor is rapidly gaining acceptance as a potent mediator in many reproductive processes. This study presents data that indicate a direct role of platelet activating factor in fertilization. Platelet activating factor was shown to significantly increase (p less than 0.001) the fertilization rate of mouse oocytes in vitro. Furthermore, CV3988, an inhibitor of platelet activating factor, was noted to significantly decrease in vitro fertilization rates at 10(-5) and 10(-4) mol/L concentrations.

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