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Effects of perinatal exposure of albino rats to chloroquine.

Authors
  • Mgbodile, M U
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1987
Volume
51
Issue
5
Pages
273–276
Identifiers
PMID: 3593808
Source
Medline
License
Unknown

Abstract

The effects of perinatal exposure of Wistar-derived albino rats to chloroquine were studied. Chronic exposure to 10 mg/kg of chloroquine phosphate during intra-uterine and postnatal life resulted in a marked decrease in neonatal and postweaning body and organ weights. The fasting blood glucose level was significantly elevated at 8 weeks of age in animals exposed to chloroquine. The observed growth retardation suggested transplacental poisoning and poisoning through milk transfer. The elevation in blood sugar level could be a consequence of possible ultrastructural and biochemical alterations of pancreatic B cells.

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