Affordable Access

deepdyve-link
Publisher Website

Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol.

Authors
  • Parker, Robert B
  • Soberman, Judith E
Type
Published Article
Journal
Pharmacotherapy
Publication Date
Jul 01, 2011
Volume
31
Issue
7
Pages
630–641
Identifiers
DOI: 10.1592/phco.31.7.630
PMID: 21923449
Source
Medline
License
Unknown

Abstract

Paroxetine significantly inhibits the metabolism of both metoprolol IR and ER, resulting in an increase in the magnitude and duration of [H9252]-blockade. The potential risk of adverse effects from excessive β-blockade may be greater with metoprolol IR than with metoprolol ER because of the significantly higher peak S-metoprolol plasma concentrations achieved with the IR formulation. Thus, if paroxetine treatment is indicated in patients receiving metoprolol, use of the ER formulation may reduce the risk of adverse effects.

Report this publication

Statistics

Seen <100 times