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The effects of pargyline and 2-phenylethylamine on D1-like dopamine receptor binding.

Authors
  • Berry, Mark D
Type
Published Article
Journal
Journal of neural transmission (Vienna, Austria : 1996)
Publication Date
Jul 01, 2011
Volume
118
Issue
7
Pages
1115–1118
Identifiers
DOI: 10.1007/s00702-010-0561-x
PMID: 21191624
Source
Medline
License
Unknown

Abstract

2-Phenylethylamine (PE) potentiates neuronal responses to dopamine by an unknown post-synaptic mechanism. Here, whether PE modifies D1-like receptor binding was examined. An unexpected effect of the monoamine oxidase inhibitor pargyline was observed, which did not involve competition for ligand binding. PE did not affect ligand binding in the presence or absence of pargyline. It is concluded that the effect of pargyline does not involve elevation of endogenous PE, and PE effects on dopaminergic neurotransmission are not due to altered D1-like receptor binding.

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