Affordable Access

Effects of parabrachial opioid antagonism on stimulation-induced feeding.

Authors
  • Carr, K D
  • Aleman, D O
  • Bak, T H
  • Simon, E J
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Apr 05, 1991
Volume
545
Issue
1-2
Pages
283–286
Identifiers
PMID: 1650277
Source
Medline
License
Unknown

Abstract

The pontine parabrachial nucleus (PBN) contains gustatory relay neurons and a high concentration of opioid receptors. To investigate the involvement of PBN opioid activity in feeding behavior, antagonists were infused into the PBN bilaterally and effects on stimulation-induced feeding were determined. Naloxone, a mu-preferring antagonist, increased the lateral hypothalamic stimulation threshold for eliciting feeding behavior while nor-binaltorphimine, a kappa-selective antagonist, did not. Neither antagonist increased threshold when infused into dorsal pontine sites outside of the PBN or the fourth ventricle. In as much as PBN contains mu and kappa but no detectable delta receptors, the present results suggest that mu opioid activity within the PBN is involved in the mediation of feeding behavior.

Report this publication

Statistics

Seen <100 times