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Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.

Authors
  • Arias, Albert J
  • Armeli, Stephen
  • Gelernter, Joel
  • Covault, Jonathan
  • Kallio, Antero
  • Karhuvaara, Sakari
  • Koivisto, Tiina
  • Mäkelä, Rauno
  • Kranzler, Henry R
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2008
Volume
32
Issue
7
Pages
1159–1166
Identifiers
DOI: 10.1111/j.1530-0277.2008.00735.x
PMID: 18537939
Source
Medline
License
Unknown

Abstract

Our finding that the therapeutic effects of targeted nalmefene were not moderated by polymorphic variation in opioid receptor genes is consistent with two recent reports showing that variation in opioid receptor genes does not moderate the response to naltrexone. However, these findings contrast with those from two other studies, in which the Asn40Asp polymorphism in OPRM1 moderated the naltrexone treatment response. Additional research is needed to clarify the role of variation in opioid receptor genes on the response to opioid antagonist treatment of alcoholism.

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