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Effects of Cycloheximide on the Response of Intestinal Mucosa to Cholera Enterotoxin

Authors
  • Daniel V. Kimberg
  • Michael Field
  • Elaine Gershon
  • Robert T. Schooley
  • Antonia Henderson
Publication Date
Jun 01, 1973
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Prior studies have indicated that effects of cholera enterotoxin (CT) on the small intestine are delayed in onset and involve an interaction with adenyl cyclase in the mucosa. It has also been shown that the administration of cycloheximide to rabbits in doses which inhibit crypt cell mitoses (20 mg/kg), diminishes CT-induced fluid production in jejunal loops. These latter studies have been interpreted as indications that CT-related intestinal secretion is a crypt cell function and that it is mediated by a CT-induced protein.

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