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Effects of a novel platelet nitric oxide donor (LA816), aspirin, clopidogrel, and combined therapy in inhibiting flow- and lesion-dependent thrombosis in the porcine ex vivo model.

Authors
Type
Published Article
Journal
Circulation
1524-4539
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
110
Issue
12
Pages
1686–1693
Identifiers
PMID: 15381660
Source
Medline

Abstract

Acute NO donation with LA816, without modifying hemodynamic parameters, provides the same inhibitory effect as that obtained with chronic treatment with clopidogrel+ASA. Moreover, LA816 provides platelet inhibitory effects in addition to those of the combined blockade of cyclooxygenase and P2y(12) receptor.

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