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The effects of nimodipine on ischemic injury of the spinal cord during thoracic aortic cross-clamping.

Authors
Type
Published Article
Journal
International angiology : a journal of the International Union of Angiology
Publication Date
Volume
15
Issue
2
Pages
153–161
Identifiers
PMID: 8803641
Source
Medline
License
Unknown

Abstract

Nimodipine used as single agent therapy failed to show a statistically significant clinical neurologic benefit. However, nimodipine significantly decreased postischemic reperfusion hyperemia in the spinal cord as measured by laser doppler flowmetry. This reduced hyperperfusion, which significantly correlated with functional outcome, may be responsible for dampening neural cell damage. Thus, nimodipine should be considered as an adjunct to a multimodality approach in the prevention of spinal cord ischemia during thoracic and thoracoabdominal aortic reconstructions.

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