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Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes.

Authors
  • Bussink, J
  • Kaanders, J H
  • Strik, A M
  • van der Kogel, A J
Type
Published Article
Journal
Radiotherapy and Oncology
Publisher
Elsevier
Publication Date
Oct 01, 2000
Volume
57
Issue
1
Pages
21–30
Identifiers
PMID: 11033185
Source
Medline
License
Unknown

Abstract

Temporal changes in local pO(2) can be measured with the OxyLite. This system was used to quantitate the effects of oxygen modifying treatments. Rapid increases in pO(2) during carbogen breathing were observed in most tumor areas. The locally measured response to nicotinamide was smaller and more variable. Bio-reductive hypoxic cell marker binding in combination with OxyLite pO(2) determination gives spatial information about the distribution patterns of tumor hypoxia at the microscopic level together with the possibility to continuously measure changes in pO(2) in specific tumor areas.

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