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Effects of Natural Products on Mcl-1 Expression and Function

Authors
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science
Publication Date
Oct 18, 2015
Volume
22
Issue
30
Identifiers
DOI: 10.2174/0929867322666150716115435
Source
LBMCC
Keywords
License
Yellow

Abstract

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural …

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