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Effects of multiple doses of voriconazole on the vision of healthy volunteers: a double-blind, placebo-controlled study.

Authors
  • Zrenner, Eberhart
  • Tomaszewski, Konrad
  • Hamlin, Julia
  • Layton, Gary
  • Wood, Nolan
Type
Published Article
Journal
Ophthalmic Research
Publisher
S. Karger AG
Publication Date
Jan 01, 2014
Volume
52
Issue
1
Pages
43–52
Identifiers
DOI: 10.1159/000359952
PMID: 24925440
Source
Medline
License
Unknown

Abstract

Effects of voriconazole on altered visual perception, ERG, color vision and static visual field thresholds are nonprogressive over a treatment period and reversible. It is hypothesized that voriconazole has a pharmacological effect on rod and cone pathways including a possible mechanism of disinhibition that reversibly puts the retina in a more light-adapted state and leads to increased relative contrast sensitivity.

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