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Effects of a Modified Chitosan Compound Combined with Lung Lavage after Inhalation of Depleted Uranium Dust.

  • Xiao, Yao1
  • Zeng, Feng1
  • Fu, Weilin1
  • Zhang, Yi1
  • Chen, Xiangyu1
  • Liang, Yi2
  • Li, Rong3
  • Liu, Minghua1
  • 1 Emergency Department, The Southwest Hospital of Third Military Medical University, Chongqing, China. , (China)
  • 2 Emergency Department, The General Hospital of Western Theater Command of PLA, Chengdu, China. , (China)
  • 3 Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing, China. , (China)
Published Article
Health physics
Publication Date
Jun 01, 2022
DOI: 10.1097/HP.0000000000001557
PMID: 35394463


When exposed to depleted uranium (DU), the respiratory tract is the main route for DU to enter the body. At present, lung lavage is considered to be a method for removing DU from the lung. However, there is still room for improvement in the efficiency of lung lavage. In this work, a model of DU dust inhalation injury was established in beagle dogs so that chitosan-diethylenetriaminepentaacetic nanoparticles (CS-DTPA NP) could be synthesized. The purpose of this work was to evaluate the removal efficiency of CS-DTPA NP combined with lung lavage in dogs. Results showed that 7 d after DU exposure, the diethylenetriaminepentaacetic (DTPA) and CS-DTPA NP groups showed lower U content in kidney tissue compared with the normal saline (NS) group. In the left lung tissue (lavage fluid and recovery rate of lavage fluid), the U content in the CS-DTPA NP group was higher than in the NS and DTPA groups. In terms of blood levels, the CS-DPTA NP group increased over time at 1, 3 and 7 d of DU exposure without lavage; however, the U levels in the 3 and 7 d lavage groups were significantly lower than in the non-lavage groups. IL-1 in the lavage fluid of the CS-DPTA NP and CS NPs group were lower than in the NS group. In summary, after respiratory exposure to DU, early inhalation of CS-DPTA NP may block insoluble DU particles in the lung, and if combined with lung lavage, the clearance efficiency of DU from lung tissue improves. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Health Physics Society.

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